X-ray structural analysis of two new potential active antimalarial drugs

A New Analysis Method for Two-dimensional X-ray Data

Improvements in X-ray optics and detectors have led to unprecedented challenges in interpreting diffraction information. One challenge is obtaining strain results from Debye-Scherrer rings originating from a few grains of material. In addition, results are typically desired from multiple rings over hundreds or thousands of exposures. Current two-dimensional analysis methods build on existing on...

Should new antimalarial drugs be subsidized?

Malaria kills over a million people each year. The loss of chloroquine due to the spread of parasite resistance is largely responsible for the resurgence of malaria. A new class of antimalarial drugs called artemisinins are available, but are unaffordable to most people in malaria-endemic countries and may quickly face the same fate as chloroquine unless they are combined with a partner drug. S...

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چکیده ندارد.

Effectiveness of antimalarial drugs.

Comparative Analysis of Novel Targets for Antimalarial Drugs: Structural and Mechanistic Insights about Plasmodium falciparum Enzymes

Plasmodium falciparum, the causative agent of severe human malaria. The dominance of resistant strains has compelled to the discovery and development of new and different modes-ofaction. Current plasmodial drug discovery efforts remains lack far-reaching set of legitimated drug targets. Prerequisite of these targets (or the pathways in which they function) is that they prove to be crucial for p...